Conference Program
Monday, September 28th
16.00 – 19.00
Registration
19:30 – 21:00
Welcome Drink & Dinner
Tuesday, September 29th
08:00 – 09:00
Breakfast
09:00 – 09:10
Opening Remarks
J. Marszałek & R. Dutkiewicz
Session 1: Prokaryotic Fe-S Cluster Synthesis & Stress Response
Chair: Jaroslaw Marszalek
09:10 – 09:40
Topic: Bacterial pathogen survival and Fe-S cluster maintenance under oxidative stress. (Title TBA)
Oral 1: Frédéric Barras (Institut Pasteur, France)
09:40 – 10:10
Topic: Bacterial oxygen/metabolic sensing and cluster-mediated transcription. (Title TBA)
Oral 2: Patricia Kiley (University of Wisconsin-Madison, USA)
10:10 – 10:40
“Functional aspects of extramitochondrial Fe/S protein maturation”
Oral 3: Oliver Stehling (Universität Marburg, Germany)
10:40 – 11:10
“Fe-S cluster biogenesis in Escherichia coli”
Oral 4: Beatrice Py (Aix-Marseille Université, France)
11:10 – 11:30
Coffee break
Session 2: Complex Clusters, Pathophysiology, & Biophysical Methods
Chair: Antonio J. Pierik
11:30 – 12:00
“The SUF Iron-Sulfur Cluster Assembly Machinery: From Escherichia coli to Mycobacterium tuberculosis”
Oral 5: Sandrine Ollagnier de Choudens (Univ. Grenoble Alpes, France)
12:00 – 12:30
“Structural Insights into Nitrogenase FeMo-Co Assembly”
Oral 6: Yvain Nicolet (Univ. Grenoble Alpes, France)
12:30 – 13:00
Topic: Pathophysiology of Frataxin deficiency and Friedreich’s ataxia. (Title TBA)
Oral 7: Hélène Puccio (University of Lyon, France)
13:00 – 13:30
“Elucidating Electron Transfer Pathways of Iron-Sulfur Proteins via Solution NMR”
Oral 8: Simone Ciofi-Baffoni (University of Florence, Italy)
13:30 – 14:30
Lunch
14:30 – 16:00
Poster Session
16:00 – 16:30
Coffee break
Session 3: Homeostasis, Biogenesis & Host-Pathogen Interactions
Chair: Nick Le Brun
16:30 – 17:00
“A non-canonical FeS cluster coordination enables ferroptosis sensing”
Oral 9: Carsten Berndt (Heinrich-Heine Universität Düsseldorf, Germany)
17:00 – 17:30
“Iron, Sulfur, and Survival: A New Role for Metallothioneins in Fungal Pathogens”
Oral 10: Caryn Outten (University of South Carolina, USA)
17:30 – 18:00
“ISC [2Fe–2S] cluster biogenesis machinery in E. coli: cluster assembly on IscU and IscR-mediated regulation”
Oral 11: Miaomiao Gao (University of East Anglia, United Kingdom)
18:00 – 18:30
Topic: Bacillus subtilis and Gram-positive prokaryotic Fe-S cluster synthesis. (Title TBA)
Oral 12: Patricia Dos Santos (Wake Forest University, USA)
18:30 – 19:00
“A Hybrid Cofactor Biosynthesis Pathway Expands Electron Transfer Options for Nitrogen Fixation”
Oral 13: Kathryn Fixen (University of Minnesota, USA)
19:30 – 20:30
Dinner
Wednesday, September 30th
08:00 – 09:00
Breakfast
Session 4: Regulation, Spectroscopy, & Chaperones
Chair: Rafal Dutkiewicz
09:00 – 09:30
“Determining the signals to which Rrf2-family Fe-S regulators respond”
Oral 14: Nick Le Brun (University of East Anglia, United Kingdom)
09:30 – 10:00
“Paramagnetic NMR is a tool to structurally characterize iron-sulfur proteins: the case of Human Ferredoxins”
Oral 15: Mario Piccioli (University of Florence, Italy)
10:00 – 10:30
“Viral Fe-S proteins: The small Cys/Gly-rich GciS protein in the giant Mimivirus”
Oral 16: Bénédicte Burlat (CNRS/AMU, Marseille, France)
10:30 – 11:00
“Molecular basis of client recognition by the mitochondrial Hsp70 Ssq1 specialized in Fe-S cluster biogenesis.”
Oral 17: Jaroslaw Marszalek (University of Gdansk, Poland)
11:00 – 11:30
Coffee break
Session 5: Enzymology & Stringent Response
Chair: Sandrine Ollagnier de Choudens
11:30 – 12:00
Topic: Fe-S cluster syntheis and quantitative kinetics. (Title TBA)
Oral 18: Benoît D’Autréaux (Paris-Saclay University, France)
12:00 – 12:30
“Bioinformatic search reveals novel types of biotin synthases”
Oral 19: Nikolas Alansson (Univ. Grenoble Alpes, France)
12:30 – 13:00
“Stress-induced iron-sulfur cluster damage as a conserved trigger of the bacterial stringent response”
Oral 20: Séverin Ronneau (University of Rennes, France)
13:00 – 13:30
“Exploring the bacterial NO stress response and regulation by sRNAs”
Oral 21: Pierre Mandin (Aix-Marseille Université, France)
13:30 –
Lunch & Free Time – Conference Guided Activities
19:30 – 20:30
Dinner
Thursday, October 1st
08:00 – 09:00
Breakfast
Session 6: Homeostasis, Interactomes, & Enzymatic Channels
Chair: Beatrice Py
09:00 – 09:30
“Iron trafficking, homeostasis, and metabolism in yeast; characterization of the labile iron pool and modeling systems-level properties.”
Oral 22: Paul Lindahl (Texas A&M University, USA)
09:30 – 10:00
“Decoding the GrxD Interactome: Insights into Fe-S Cluster Delivery and Trafficking in E. coli”
Oral 23: Wayne Outten (University of South Carolina, USA)
10:00 – 10:30
“A hydrosulfide channel connects cysteine desulfurase to the [4Fe-4S] cluster of D-type MnmA for tRNA anticodon sulfuration”
Oral 24: Beatrice Golinelli-Pimpaneau (Collège de France, France)
10:30 – 11:00
“CyaY and TusA regulate ISC- and SUF-mediated L-cysteine desulfurase activity”
Oral 25: Silke Leimkühler (University of Potsdam, Germany)
11:00 – 11:30
Coffee break
Session 7: Cytosolic Pathways, Photosynthesis, & Parasitology
Chair: Simone Ciofi-Baffoni
11:30 – 12:00
“Molecular Decoding Principles Mediating Client Recognition in the CIA Pathway”
Oral 26: Deborah L. Perlstein (Boston University, USA)
12:00 – 12:30
“The Fe-S cluster carrier, high-chlorophyll fluorescence 101, is primarily required for the light metabolism in Chlamydomonas chloroplasts”
Oral 27: Nicolas Rouhier (Université de Lorraine-INRAE, France)
12:30 – 13:00
“The late ISC component ISCA2 supports cytosolic and nuclear Fe-S protein maturation in Giardia intestinalis”
Oral 28: Pavel Doležal (Charles University, Czech Republic)
13:00 – 13:30
“Structure, function, spectroscopy, and biosynthesis of histidine-coordinated [2Fe-2S] proteins”
Oral 29: Antonio J. Pierik (RPTU University Kaiserslautern-Landau, Germany)
13:30 – 14:30
Lunch
Session 8: Sulfur Transfer, Pathogens, & Quantum Chemistry
Chair: Patricia Dos Santos
14:30 – 15:00
Topic: Staphylococcus aureus respiratory networks and iron-sulfur protection. (Title TBA)
Oral 30: Jeffrey Boyd (Rutgers University, USA)
15:00 – 15:30
“The structure of SufBC2D-SufE complex reveals mechanisms of sulfur transfer in the Suf pathway for Fe-S cluster assembly”
Oral 31: Patrick A. Frantom (The University of Alabama, USA)
15:30 – 16:00
“Biosynthesis and functional role of iron–sulfur clusters in carbon monoxide dehydrogenase”
Oral 32: Christine Cavazza (Univ. Grenoble Alpes, France)
16:00 – 17:00
“Reaction Pathways of IspH, an FeS Enzyme in Pathogenic Bacteria based on Quantum Chemistry and Protein Electrostatics”
Oral 33: Louis Noodleman (The Scripps Research Institute, USA)
17:00 – 17:30
Coffee break
Session 9: Human Disease & Mitochondrial Mechanisms
Chair: Mario Piccioli
17:30 – 18:00
“Mutations in FDX2 or NFS1 suppress frataxin deficiency”
Oral 34: Joshua Meisel (Brandeis University, USA)
18:00 – 18:30
“Perturbation of cytosolic iron–sulfur cluster biogenesis reshapes pre-60S ribosome maturation through the [4Fe-4S] protein Mak16”
Oral 35: Daili J. Netz (RPTU University of Kaiserslautern-Landau, Germany)
18:30 – 19:00
“Molecular mechanisms of the assembly of iron-sulfur clusters by the SUF machinery in chloroplasts”
Oral 36: Benjamin Das Neves (Université de Lorraine-INRAE, France)
19:00 – 19:45
“Mechanisms of mitochondrial iron-sulfur protein assembly”
Oral 37: Roland Lill (Philipps-Universität Marburg, Germany)
19:45
Closing Remarks
20:30 – 23:00
Conference Banquet